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Reversing Skin Aging from the Inside Out

Insights from the Landmark 2026 Dihydromyricetin (DHM) Epigenetic Study

An image of Dihydromyricetin and the ampelopsis grossedentata plant

One of the most exciting developments in 2026 so far is the publication of a new clinical study in Dermatology and Therapy with dihydromyricetin (DHM), a natural flavonoid now trademarked by Beiersdorf as Epicelline®, for its ability to reverse epigenetic signs of skin aging.

The study, titled “Epigenetic Skin Aging and Its Reversal to Improve Skin Longevity across Ethnicities and Phototypes Using a Dihydromyricetin-Containing Serum,” delivers some compelling early evidence that targeted epigenetic modulation could be the next innovation for skin health and longevity. 

Here’s what the research shows, its limitations, practical product options, and what you should know if you’re considering DHM in topical or oral form.

The Study at a Glance

This was a prospective, single-cohort clinical trial involving 60 diverse participants (ages 40–70, Fitzpatrick phototypes I–VI) from a multi-ethnic Brazilian population, plus a smaller pilot methylome analysis of 17 donors. Volunteers applied a DHM-containing facial serum (Beiersdorf product code E004079A-01, now commercially available as Eucerin Hyaluron-Filler Epigenetic Serum) twice daily for 8 weeks, combined with daily sunscreen.

Key findings included:

  • A statistically significant reduction in epidermal DNA methylation age (average ~2.1 years reversal, with 40% of participants showing ≥5 years reduction).
  • Visible and structural improvements: 13.9% reduction in wrinkle visibility, 12.3% in wrinkle occupancy, decreased skin roughness, and increased dermal echogenicity (a marker of collagen density).
  • Benefits observed across ethnicities, phototypes, and genders, with epigenetic changes correlating to clinical skin rejuvenation.

 

The researchers conclude that epigenetic aging signatures are conserved across populations and that DHM can help “rejuvenate skin cells, restore regulatory landscapes, and reactivate youth-associated genes.”

 

Study Design Shortcomings to Keep in Mind

While promising, the study has important limitations that temper enthusiasm and highlight the need for more research:

  • No placebo or vehicle-controlled arm in the main product-use phase (though prior Beiersdorf vehicle-controlled studies supported DHM’s effects).
  • Short duration (only 8 weeks); longer-term follow-up is needed to assess durability of epigenetic and clinical changes.
  • Demographic imbalances: Underrepresentation of Asian participants and males.
  • Industry involvement: Funded by Beiersdorf AG, with several authors employed by or consulting for the company—standard in product development but worth noting for potential bias.
  • Focus primarily on DNA methylation clocks; broader omics data (e.g., transcriptomics) could provide deeper mechanistic insights.


These are common in early-stage cosmetic clinical studies. Independent, longer, placebo-controlled trials will be valuable next steps.

Skincare Products Containing Dihydromyricetin (DHM / Epicelline®)

DHM is already available in several professionally formulated products. The star player tied directly to the study is:

Eucerin Hyaluron-Filler Epigenetic Serum (with Epicelline® + hyaluronic acid, glycine saponin, and enoxolone), the exact formulation used in the trial. Other notable options include:

 

You can always check current INCI list for skincare products that contain Dihydromyricetin. 

 

DHM as an Oral Supplement: Potential Benefits, Dosing, and Caveats

DHM has a long history of traditional use (especially in vine tea from Ampelopsis grossedentata) and is widely available as a dietary supplement. It shows promising preclinical anti-aging effects through multiple mechanisms, including strong antioxidant activity, reduction of inflammation, promotion of autophagy, modulation of key longevity pathways (e.g., SIRT1, FOXO, AMPK, mTOR), and epigenetic effects

Potential benefits (supported by preclinical and limited human data):

  • Strong antioxidant and anti-inflammatory effects.
  • Liver protection (including hangover relief and potential support for fatty liver).
  • Metabolic benefits (e.g., blood sugar regulation, cholesterol support).
  • Possible neuroprotective and anti-alcohol intoxication properties via GABA receptor modulation.
  • Acts as a RAGE (receptor for advanced glycation end-products) inhibitor, helping reduce glycation-induced skin aging
  • Provide indirect cardiovascular protection through antioxidant, anti-inflammatory, and anti-fibrotic effects 
  • Human evidence is strongest for short-term liver/alcohol-related uses; broader anti-aging claims are emerging but preliminary.

 

DHM Typical Dosing Guidelines

  • General wellness: 300 – 1,000 mg per day.
  • Hangover/alcohol support: Often 300 mg per standard drink or 2,000 – 4,000 mg as a loading dose (taken before or during drinking).

 

DHM Contraindications & Safety

  • Generally well-tolerated with a strong safety profile in short-term studies; no major toxicity reported at typical doses.
  • Mild side effects possible: gastrointestinal upset, headache, or dizziness.
  • Potential drug interactions due to CYP enzyme inhibition (e.g., CYP3A4, CYP2D6), consult a physician if on medications.
  • Avoid or use extreme caution if you have hypotension (low blood pressure), are on blood pressure medications, or have conditions affected by GABA modulation. 
  • Not recommended during pregnancy/breastfeeding without medical advice.

 

DHM Oral Supplement Sourcing Caveats

  • DHM has low bioavailability and poor stability. Choose high-purity (>98%) products from reputable brands.
  • Prioritize third-party tested supplements (for heavy metals, microbes, potency) from cGMP facilities.
  • Avoid unverified cheap imports; look for transparent Certificates of Analysis (e.g., from brands like Double Wood or similar vetted suppliers).
  • Oral DHM is not a substitute for a healthy lifestyle, and topical use (as in the study) targets skin more directly.
 

This 2026 DHM study adds exciting momentum to the field of epigenetic skincare and regenerative aesthetics.

Rejuvience Med Spa in Scottsdale is a regenerative aesthetics practice. We integrate evidence-based treatment modalities, topicals, advanced peptides, exosomes, and personalized regenerative protocols to promote healthier, more youthful skin from the inside and out.

If you’re curious about what today’s regenerative aesthetics technology can do for your skin’s health and appearance, we invite you to schedule a complimentary consultation

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Scottsdale Regenerative Insider is the official blog of Rejuvience Med Spa. We believe in transparent, evidence-based aesthetics that utilize your body’s natural ability to heal and renew.

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